C-7280948
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $950 | Check With Us |
| 1g | $1425 | Check With Us |
: Cat #: V2926 CAS #: 587850-67-7 Purity ≥ 98%
Description: C-7280948 (C7280948) is a selective PRMT1 (protein arginine methyltransferase) inhibitor with anticancer activity.
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| Molecular Weight (MW) | 276.35 |
|---|---|
| Molecular Formula | C14H16N2O2S |
| CAS No. | 587850-67-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 38 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | O=S(C1=CC=C(N)C=C1)(NCCC2=CC=CC=C2)=O |
| Synonyms | C-7280948; C 7280948; C7280948 |
| Protocol | In Vitro | C-7280948 is compound 6a in this article, it against hPRMT1 with an IC50 value of 12.75 μM. Especially arginine methyltransferases also target non-histone protein substrates and are therefore often called protein methyltransferases (PRMTs). The subtype PRMT1 has been linked to the activation of estrogen and androgen receptors and therefore may represent a new treatment option for hormone-dependent cancer. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6186 mL | 18.0930 mL | 36.1860 mL | 72.3720 mL |
| 5mM | 0.7237 mL | 3.6186 mL | 7.2372 mL | 14.4744 mL |
| 10mM | 0.3619 mL | 1.8093 mL | 3.6186 mL | 7.2372 mL |
| 20mM | 0.1809 mL | 0.9046 mL | 1.8093 mL | 3.6186 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.