Sinefungin | CAS 58944-73-3

Sinefungin

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1850	To Be Confirmed
200mg	$2775	To Be Confirmed
500mg	$4680	To Be Confirmed

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Cat #: V3457 CAS #: 58944-73-3 Purity ≥ 98%

Description: Sinefungin (Adenosyl-Ornithine, Antibiotic 32232RP, A-9145) is a 5′-aminoalkyl analog of SAH and a natural product from cultures of Streptomyces incamatus and S. griseolus, acting as a novel and potent inhibitor of histone G9a and DNA methyltransferase.

References: Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	381.39
Molecular Formula	C15H23N7O5
CAS No.	58944-73-3
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C(O)[C@@H](N)CC[C@H](N)C[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
Synonyms	Sinefungin; Adenosylornithine; Antibiotic A 9145;Antibiotic A 9145; Antibiotic 32232RP; RP32232; RP-32232; RP 32232

Protocol	In Vitro	Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells.
Protocol	In Vivo	Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6220 mL	13.1099 mL	26.2199 mL	52.4398 mL
5mM	0.5244 mL	2.6220 mL	5.2440 mL	10.4880 mL
10mM	0.2622 mL	1.3110 mL	2.6220 mL	5.2440 mL
20mM	0.1311 mL	0.6555 mL	1.3110 mL	2.6220 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.