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DS-437

This product is for research use only, not for human use. We do not sell to patients.

DS-437
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$650To Be Confirmed
200mg$975To Be Confirmed
500mg$1645To Be Confirmed
email: [email protected]        [email protected]

Cat #: V20268 CAS #: 1674364-87-4 Purity ≥ 99%

Description: DS-437 (DS437) is a novel and potent dual PRMT5 and PRMT7 inhibitor with anticancer activity.

References: Smil D, et al. Discovery of a Dual PRMT5-PRMT7 Inhibitor.ACS Med Chem Lett. 2015 Mar 2;6(4):408-12.

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Molecular Weight (MW)397.45
Molecular FormulaC15H23N7O4S
CAS No.1674364-87-4
SynonymsDS437; DS 437; DS-437
ProtocolIn VitroDS-437 was able to inhibit methylation of an H4[1–24] peptide by the PRMT5–MEP50 complex under balanced conditions (cofactor and substrate concentrations set at their respective Km values) in a dose-dependent manner with an IC50 of 5.9 ± 1.4 μM.
In VivoDS-437 (10 mg/kg; i.p.; 5 times a week) has some beneficial effects on inhibiting tumor growth. The combination of DS-437 and the anti-p185erbB2/neu antibody 4D5 had even more dramatic effects.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.5160 mL12.5802 mL25.1604 mL50.3208 mL
5mM0.5032 mL2.5160 mL5.0321 mL10.0642 mL
10mM0.2516 mL1.2580 mL2.5160 mL5.0321 mL
20mM0.1258 mL0.6290 mL1.2580 mL2.5160 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.