GSK3368715 dihydrochloride

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$850	Check With Us
200mg	$1275	Check With Us
500mg	$2150	Check With Us

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Cat #: V32456 CAS #: 1628925-77-8 Purity ≥ 99%

Description: GSK3368715 dihydrochloride (GSK-3368715; EPZ-019997; EPZ019997), the dihydrochloride salt of GSK3368715, is a potent and orally bioavailable inhibitor of type I PRMTs (protein arginine methyltransferases) with potential anticancer activity.

References: Fedoriw A, et al. Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell. 2019 Jul 8;36(1):100-114.e25.

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Molecular Weight (MW)	439.46
Molecular Formula	C20H40Cl2N4O2
CAS No.	1628925-77-8
SMILES Code	CNCCN(CC1=CNN=C1C2CCC(COCC)(COCC)CC2)C.[H]Cl.[H]Cl
Synonyms	GSK3368715 dihydrochloride; GSK-3368715 dihydrochloride; GSK 3368715 dihydrochloride

Protocol	In Vitro	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) shows 50% or more growth inhibition relative to DMSO-treated cells in the majority of 249 cancer cell lines, representing 12 tumor types.
Protocol	In Vivo	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) significantly effects on the growth of BxPC3 xenografts at all doses tested, reducing tumor growth by 78% and 97% in the 150- and 300-mg/kg dose groups, respectively.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2755 mL	11.3776 mL	22.7552 mL	45.5104 mL
5mM	0.4551 mL	2.2755 mL	4.5510 mL	9.1021 mL
10mM	0.2276 mL	1.1378 mL	2.2755 mL	4.5510 mL
20mM	0.1138 mL	0.5689 mL	1.1378 mL	2.2755 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.