EPZ011989
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $1100 | Check With Us |
| 1g | $1650 | Check With Us |
: Cat #: V20662 CAS #: 1598383-40-4 Purity ≥ 99%
Description: EPZ011989 (EPZ-011989) is a potent, orally bioavailable EZH2 inhibitor with high anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 605.81 |
|---|---|
| Molecular Formula | C35H51N5O4 |
| CAS No. | 1598383-40-4 |
| SMILES Code | O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C#CCN3CCOCC3)=CC(N(CC)[C@H]4CC[C@H](N(CCOC)C)CC4)=C2C |
| Synonyms | EPZ-011989; EPZ011989; EPZ 011989 |
| Protocol | In Vitro | EPZ011989 (0-10 μM; 11 days) has anti-proliferation effect in WSU-DLCL2 cells. EPZ011989 reduces cellular H3K27 methylation with an IC50 value of 94 nM. EPZ011989 inhibits mutant and wild-type EZH2 with an Ki value of <3 nM. |
|---|---|---|
| In Vivo | EPZ011989 (oral; 30-1000 mg/kg; single or bid; for 7 days or 21 days) can elicit robust methyl mark inhibition and antitumor activity. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6507 mL | 8.2534 mL | 16.5068 mL | 33.0137 mL |
| 5mM | 0.3301 mL | 1.6507 mL | 3.3014 mL | 6.6027 mL |
| 10mM | 0.1651 mL | 0.8253 mL | 1.6507 mL | 3.3014 mL |
| 20mM | 0.0825 mL | 0.4127 mL | 0.8253 mL | 1.6507 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.