DDP-38003 dihydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1400 | Check With Us |
| 250mg | $2100 | Check With Us |
| 500mg | $3150 | Check With Us |
: Cat #: V2936 CAS #: 1831167-98-6 Purity ≥ 98%
Description: DDP-38003 dihydrochloride, a tranylcypromine (TCPA) derivative, is a novel, potent and orally bioavailable inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 423.38 |
|---|---|
| Molecular Formula | C21H28Cl2N4O |
| CAS No. | 1831167-98-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 29 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | O=C(NC1=CC=C([C@H]2[C@H](N)C2)C=C1)C3=CC=C(N4CCN(C)CC4)C=C3.[H]Cl.[H]Cl |
| Synonyms | DDP-38003 dihydrochloride; DDP 38003 dihydrochloride; DDP38003 dihydrochloride; DDP-38003 2HCl; DDP 38003 2HCl; DDP38003 2HCl |
| Protocol | In Vitro | DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. |
|---|---|---|
| In Vivo | DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3619 mL | 11.8097 mL | 23.6194 mL | 47.2389 mL |
| 5mM | 0.4724 mL | 2.3619 mL | 4.7239 mL | 9.4478 mL |
| 10mM | 0.2362 mL | 1.1810 mL | 2.3619 mL | 4.7239 mL |
| 20mM | 0.1181 mL | 0.5905 mL | 1.1810 mL | 2.3619 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.