Procaine (Novocaine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100g | $800 | Check With Us |
| 200mg | $1200 | Check With Us |
| 500mg | $2025 | Check With Us |
: Cat #: V29996 CAS #: 59-46-1 Purity ≥ 99%
Description: Procaine (also known as Novocaine HCl), the HCl salt of the local anesthetic Procaine, is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.
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| Molecular Weight (MW) | 236.31 |
|---|---|
| Molecular Formula | C13H20N2O2 |
| CAS No. | 59-46-1 |
| SMILES Code | O=C(OCCN(CC)CC)C1=CC=C(N)C=C1 |
| Synonyms | Procaine |
| Protocol | In Vitro | Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.2317 mL | 21.1586 mL | 42.3173 mL | 84.6346 mL |
| 5mM | 0.8463 mL | 4.2317 mL | 8.4635 mL | 16.9269 mL |
| 10mM | 0.4232 mL | 2.1159 mL | 4.2317 mL | 8.4635 mL |
| 20mM | 0.2116 mL | 1.0579 mL | 2.1159 mL | 4.2317 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.