GSK-LSD1 2HCl | CAS 1821798-25-7 (2HCl)

GSK-LSD1 2HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$1150	Check With Us
500mg	$1850	Check With Us
1g	$2775	Check With Us

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Cat #: V0376 CAS #: 1821798-25-7 (2HCl) Purity ≥ 98%

Description: GSK-LSD1 2HCl, the dihydrochloride salt of GSK-LSD1 (GSK-LSD-1), is an irreversible, potent and selective inhibitor of Lysine (K) -specific demethylase 1A (LSD1) with antineoplastic activity.

References: Li Yan, et al. Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. 2009.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	289.24
Molecular Formula	C14H22Cl2N2
CAS No.	1821798-25-7 (2HCl)
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 60 mg/mLr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	[H]Cl.[H]Cl.C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1
Synonyms	GSK-LSD1 dihydrochloride; GSK-LSD1; GSK-LSD 1; GSK-LSD-1; GSK-LSD1 2HCl; GSK-LSD1 (trans-racemic) dihydrochloride; GSK-LSD1 HCl;

Protocol	In Vitro	MK-2206 dihydrochloride (MK-2206 (2HCl)) (0-10 μM; 72 and 96 hours) inhibits the nasopharyngeal carcinoma (NPC) cell lines CNE-1, CNE-2, HONE-1, and SUNE-1 proliferation in dose- and time-dependent manner.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.4573 mL	17.2867 mL	34.5734 mL	69.1467 mL
5mM	0.6915 mL	3.4573 mL	6.9147 mL	13.8293 mL
10mM	0.3457 mL	1.7287 mL	3.4573 mL	6.9147 mL
20mM	0.1729 mL	0.8643 mL	1.7287 mL	3.4573 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.