NSC-741764
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2050 | Check With Us |
| 200mg | $3075 | Check With Us |
| 500mg | $5190 | Check With Us |
: Cat #: V2301 CAS #: 849669-54-1 Purity ≥ 99%
Description: NSC-741764 ( also known as AQX-016A), is a novel and potent activator of SHIP-1 .
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 328.49 |
|---|---|
| Molecular Formula | C22H32O2 |
| CAS No. | 849669-54-1 |
| SMILES Code | OC1=C(O)C2=C(C(C)=C1)[C@]3(C)CCC(C(C)(C)CCC4)[C@@]4(C)[C@@]3([H])C2 |
| Synonyms | NSC-741764; NSC 741764; NSC741764; AQX-016A; AQX 016A; AQX016A; |
| Protocol | In Vitro | AQX-016A (0-5 μg/mL, 0-90 min) inhibits TNFa translation. AQX-016A (0-6 μg/mL, 30 min) requires SHIP to maximally inhibit TNFa production in BMDM, selectively inhibits TNF production from SHIP1+/+ but not SHIP1-/- macrophages. AQX-016A (0-5 μg/mL, 2 h) significantly inhibits TNFa in both J774 and peritoneal macrophages at both 1 and 5 μg/mL. AQX-01 6A (0-5 μg/mL, 30 min) inhibits LPS-induced PKB phosphorylation in a SHIP dependent manner. AQX-016A (5 μg/mL, 30 min) inhibits the PI3K-mediated increase in intracellular PIP3 levels, and reduces PIP3 levels through activation of a 5 'phosphatase enzyme. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0442 mL | 15.2212 mL | 30.4423 mL | 60.8847 mL |
| 5mM | 0.6088 mL | 3.0442 mL | 6.0885 mL | 12.1769 mL |
| 10mM | 0.3044 mL | 1.5221 mL | 3.0442 mL | 6.0885 mL |
| 20mM | 0.1522 mL | 0.7611 mL | 1.5221 mL | 3.0442 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.