VY-3-135
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1800 | Check With Us |
| 250mg | $3200 | Check With Us |
| 500mg | $4800 | Check With Us |
: Cat #: V3929 CAS #: 1824637-41-3 Purity ≥ 99%
Description: VY3-135 (VY-3135; VY3135) is a novel and potent ACSS2 (acetyl-CoA synthetase 2) inhibitor ( IC50 = 44 nM) with antitumor effects.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 429.51 |
|---|---|
| Molecular Formula | C26H27N3O3 |
| CAS No. | 1824637-41-3 |
| SMILES Code | O=C(C1=CC=C2C(N(CC)C(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2)=C1)NC[C@H](O)C |
| Synonyms | VY-3-135; VY3-135; VY 3-135; VY-3135; VY3135; VY 3135; |
| Protocol | In Vitro | VY-3-135 (0.1, 1 μM; for 24 hours) blocks acetate dependent labeling of palmitate by 13C2-acetate in ACSS2low A7C11 and ACSS2high Brpkp110 cells. |
|---|---|---|
| In Vivo | VY-3-135 (100 mg/kg/day; PO; 30 days) represses MDA-MB-468 (ACSS2high) tumor growth but is mostly ineffective at blocking WHIM12 (ACSS2low) growth. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3282 mL | 11.6412 mL | 23.2823 mL | 46.5647 mL |
| 5mM | 0.4656 mL | 2.3282 mL | 4.6565 mL | 9.3129 mL |
| 10mM | 0.2328 mL | 1.1641 mL | 2.3282 mL | 4.6565 mL |
| 20mM | 0.1164 mL | 0.5821 mL | 1.1641 mL | 2.3282 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.