Solcitinib
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
Size | Price | Stock |
---|---|---|
250mg | $750 | Check With Us |
500mg | $1250 | Check With Us |
1g | $1875 | Check With Us |
Cat #: V2959 CAS #: 1206163-45-2 Purity ≥ 98%
Description: Solcitinib (formerly GSK2586184; GSK-2586184A; GLPG-0778; GLPG0778) is a potent, selective, and orally bioavailable Janus kinase (JAK)1 inhibitor being evaluated as a treatment for moderate-to-severe plaque-type psoriasis.
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Molecular Weight (MW) | 389.45 |
---|---|
Molecular Formula | C22H23N5O2 |
CAS No. | 1206163-45-2 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: 20 mg/mLr |
Water: <1 mg/mLr | |
Ethanol: <1 mg/mL | |
SMILES Code | O=C(C1CC1)NC2=NN3C(C4=CC=C(C(N5CC(C)(C)C5)=O)C=C4)=CC=CC3=N2 |
Synonyms | GLPG-0778; GSK-2586184; GSK2586184A; GLPG 0778; GLPG0778; GSK 2586184; GSK-2586184A; G154578; GSK2586184; GSK 2586184A; Solcitinib |
Protocol | In Vitro | Solcitinib is an orally active, competitive, potent, selective JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively. Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis. |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.5677 mL | 12.8386 mL | 25.6772 mL | 51.3545 mL |
5mM | 0.5135 mL | 2.5677 mL | 5.1354 mL | 10.2709 mL |
10mM | 0.2568 mL | 1.2839 mL | 2.5677 mL | 5.1354 mL |
20mM | 0.1284 mL | 0.6419 mL | 1.2839 mL | 2.5677 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.