SS-208

This product is for research use only, not for human use. We do not sell to patients.

SS-208
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Size Price Stock
100mg$1750Check With Us
200mg$2625Check With Us
500mg$4425Check With Us

Cat #: V31449 CAS #: 2245942-72-5 Purity ≥ 99%

Description: SS-208 is a novel, potent and selective HDAC6 inhibitor, with an IC50 of 12 nM and with anti-tumor activity.

References: Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4.

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Molecular Weight (MW)344.15
Molecular FormulaC13H11Cl2N3O4
CAS No.2245942-72-5
SMILES CodeO=C(C1=NOC(CCNC(C2=CC=C(Cl)C(Cl)=C2)=O)=C1)NO           
SynonymsSS-208; SS 208; SS208
ProtocolIn VitroSS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9057 mL14.5285 mL29.0571 mL58.1142 mL
5mM0.5811 mL2.9057 mL5.8114 mL11.6228 mL
10mM0.2906 mL1.4529 mL2.9057 mL5.8114 mL
20mM0.1453 mL0.7264 mL1.4529 mL2.9057 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.