Home > Signaling Pathways>DNA Damage>HDAC >SR-4370
SR-4370

This product is for research use only, not for human use. We do not sell to patients.

SR-4370
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$960Check With Us
500mg$1350Check With Us
1g$2025Check With Us
email: [email protected]        [email protected]

Cat #: V3192 CAS #: 1816294-67-3 Purity ≥ 98%

Description: SR-4370 is an inhibitor of HDAC (Histone deacetylases), with IC50 values of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

References: LIAO, Daiqing, et al. HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT. WO 2015153516 A1.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)304.34
Molecular FormulaC17H18F2N2O
CAS No.1816294-67-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: ≥ 150 mg/mLr
Water:r
Ethanol:
SMILES CodeO=C(C1=CC=C(C2=CC=CC(F)=C2F)C=C1)NNCCCC
SynonymsSR4370; SR 4370; SR-4370
ProtocolIn VitroSR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2858 mL16.4290 mL32.8580 mL65.7160 mL
5mM0.6572 mL3.2858 mL6.5716 mL13.1432 mL
10mM0.3286 mL1.6429 mL3.2858 mL6.5716 mL
20mM0.1643 mL0.8214 mL1.6429 mL3.2858 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.