(S)-crizotinib

This product is for research use only, not for human use. We do not sell to patients.

(S)-crizotinib
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1250Check With Us
500mg$2050Check With Us
1g$3075Check With Us

Cat #: V1939 CAS #: 1374356-45-2 Purity ≥ 98%

Description: (S)-crizotinib, the (S)-enantiomer of crizotinib, is a novel and potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.

References: Huber KV, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508(7495):222-7.

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Molecular Weight (MW)450.34
Molecular FormulaC21H22Cl2FN5O
CAS No.1374356-45-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 42 mg/mL (93.3 mM)r
Water: <1 mg/mLr
Ethanol: 22 mg/mL (48.9 mM)
SMILES CodeNC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
SynonymsS-Crizotinib; PF-2341066; PF2341066; PF02341066; PF-02341066; PF 2341066 Chemical Name: 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine InChi Key: KTEIFNKAUNYNJU-LBPRGKRZSA-N InChi Code: InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m0/s1 SMILES Code: NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2205 mL11.1027 mL22.2054 mL44.4109 mL
5mM0.4441 mL2.2205 mL4.4411 mL8.8822 mL
10mM0.2221 mL1.1103 mL2.2205 mL4.4411 mL
20mM0.1110 mL0.5551 mL1.1103 mL2.2205 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.