PNU282987 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V4085 CAS #: 123464-89-1 Purity ≥ 98%
Description: PNU-282987 is a novel, potent and selective agonist of α7 nicotinic acetylcholine receptor(α7 nAChR) with Ki of 26 nM; it has no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 301.21 |
|---|---|
| Molecular Formula | C14H18Cl2N2O |
| CAS No. | 123464-89-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 45mg/mLr |
| Water: 10 mg/mLr | |
| Ethanol: 4 mg/mL | |
| SMILES Code | O=C(N[C@H]1CN2CCC1CC2)C3=CC=C(Cl)C=C3.[H]Cl |
| Synonyms | PNU-282,987; PNU 282,987; PNU282987 HCl; PNU282987; PNU-282987; PNU 282987; PNU282,987; PNU282987 hydrochloride |
| Protocol | In Vitro | PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM. PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM. PNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM. |
|---|---|---|
| In Vivo | PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner. PNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3199 mL | 16.5997 mL | 33.1994 mL | 66.3989 mL |
| 5mM | 0.6640 mL | 3.3199 mL | 6.6399 mL | 13.2798 mL |
| 10mM | 0.3320 mL | 1.6600 mL | 3.3199 mL | 6.6399 mL |
| 20mM | 0.1660 mL | 0.8300 mL | 1.6600 mL | 3.3199 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.