PF-05175157

This product is for research use only, not for human use. We do not sell to patients.

PF-05175157
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$750Check With Us
500mg$1250Check With Us
1g$1875Check With Us

Cat #: V4450 CAS #: 1301214-47-0 Purity ≥ 98%

Description: PF-05175157 (PF05175157) is a novel, potent and selective broad spectrum inhibitor of acetyl-CoA carboxylase (ACC) with anti-diabetic and anticancer activity.

References: David A, et al. Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J Med Chem. 2014 Dec 26; 57(24): 10512–10526.

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Product Promise

Promise
Molecular Weight (MW)405.49
Molecular FormulaC23H27N5O2
CAS No.1301214-47-0
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeO=C1CC2(CCN(C(C3=CC=C4N=C(C)NC4=C3)=O)CC2)CC5=C1N(C(C)C)N=C5
SynonymsPF-05175157; PF05175157; PF 05175157
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4662 mL12.3308 mL24.6615 mL49.3230 mL
5mM0.4932 mL2.4662 mL4.9323 mL9.8646 mL
10mM0.2466 mL1.2331 mL2.4662 mL4.9323 mL
20mM0.1233 mL0.6165 mL1.2331 mL2.4662 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.