SGC GAK 1

This product is for research use only, not for human use. We do not sell to patients.

SGC GAK 1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$2165Check With Us
500mg$3500Check With Us
1g$5250Check With Us

Cat #: V14713 CAS #: 2226517-76-4 Purity ≥ 98%

Description: SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor that targets the ATP-binding site.

References: Asquith CRM, et al. SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). J Med Chem. 2019 Feb 26.

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Product Promise

Promise
Molecular Weight (MW)389.24
Molecular FormulaC18H17BrN2O3
CAS No.2226517-76-4
SMILES CodeCOC1=C(OC)C(OC)=CC(NC2=CC=NC3=CC=C(Br)C=C23)=C1
SynonymsSGCGAK1; SGC GAK 1; SGC-GAK-1; SGCGAK-1; SGC-GAK1
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.5691 mL12.8455 mL25.6911 mL51.3822 mL
5mM0.5138 mL2.5691 mL5.1382 mL10.2764 mL
10mM0.2569 mL1.2846 mL2.5691 mL5.1382 mL
20mM0.1285 mL0.6423 mL1.2846 mL2.5691 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.