OSU-03012 (AR-12)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$720	Check With Us
500mg	$1150	Check With Us
1g	$1725	Check With Us

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Cat #: V0234 CAS #: 742112-33-0 Purity ≥ 98%

Description: OSU-03012 (also called AR12), a celecoxib derivative without COX-2 inhibitory activity, is an orally bioavailable, specific, and potent inhibitor of recombinant PDK-1 (3-phosphoinositide-dependent kinase-1) with potential antitumor activity.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	460.45
Molecular Formula	C26H19F3N4O
CAS No.	742112-33-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 11 mg/mL (23.9 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	0.5% methylcellulose+0.2% Tween 80: 30mg/mL
SMILES Code	O=C(NC1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C4C5=CC=CC=C5C=CC4=C3)C=C1)CN
Synonyms	AR12; AR 12; AR-12; OSU-03012; OSU03012; OSU 03012

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1718 mL	10.8589 mL	21.7179 mL	43.4358 mL
5mM	0.4344 mL	2.1718 mL	4.3436 mL	8.6872 mL
10mM	0.2172 mL	1.0859 mL	2.1718 mL	4.3436 mL
20mM	0.1086 mL	0.5429 mL	1.0859 mL	2.1718 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.