Everolimus (RAD-001, SDZ-RAD)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | In Stock |
| 1g | $700 | In Stock |
| 5g | $1770 | In Stock |
: Cat #: V0175 CAS #: 159351-69-6 Purity ≥ 98%
Description: Everolimus (formerly also known as RAD001, SDZ-RAD, or the 40-O-(2-hydroxyethyl) derivative of sirolimus) is a potent and orally bioavailable inhibitor of mammalian target of rapamycin (mTOR) with immunosuppressive activity.
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- Related Biological Data
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| Molecular Weight (MW) | 958.22 |
|---|---|
| Molecular Formula | C53H83NO14 |
| CAS No. | 159351-69-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (104.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 7 mg/mL (7.3 mM) | |
| Solubility In Vivo | 30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O: 5 mg/mL |
| SMILES Code | O=C(C(N1CCCC[C@@]1([H])C(O[C@H]([C@H](C)C[C@H]2C[C@@H](OC)[C@H](OCCO)CC2)CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]3OC)=O)=O)=O)[C@@](O4)(O)[C@H](C)CC[C@@]4([H])C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C3=O |
| Synonyms | RAD-001; RAD001; RAD 001.SDZ-RAD; Everolimus; Brand name Afinitor; Zortress; Certican; Zortress; Xience V |
| Protocol | In Vitro | Everolimus (RAD001) is an orally active derivative of rapamycin that inhibits the Ser/Thr kinase, mTOR. |
|---|---|---|
| In Vivo | Everolimus is orally active in both mice and rats, producing an antitumor effect that is characterized by dramatic reduction in tumor growth rates as opposed to producing tumor regressions. In the rat CA20498 model, daily treatment with Everolimus (0.5 or 2.5 mg/kg) dose-dependently inhibits growth, and intermittent dosing using a higher dose of 5 mg/kg (once or twice per week) also shows similar antitumor efficacy. Inhibition by Everolimus is characterized by sustained suppression rather than regression and is not associated with any body weight loss. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.0436 mL | 5.2180 mL | 10.4360 mL | 20.8720 mL |
| 5mM | 0.2087 mL | 1.0436 mL | 2.0872 mL | 4.1744 mL |
| 10mM | 0.1044 mL | 0.5218 mL | 1.0436 mL | 2.0872 mL |
| 20mM | 0.0522 mL | 0.2609 mL | 0.5218 mL | 1.0436 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
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C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.