L-Leucine-1-13C

This product is for research use only, not for human use. We do not sell to patients.

L-Leucine-1-13C
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$400To Be Confirmed
2g$650To Be Confirmed
5g$1095To Be Confirmed

Cat #: V15518 CAS #: 74292-94-7 Purity ≥ 99%

Description: L-Leucine-1-13C is the 13C-labeled form of L-Leucine, which is an essential amino acid used in the biosynthesis of proteins.

References: Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

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Molecular Weight (MW)132.17
Molecular FormulaC513CH13NO2
CAS No.74292-94-7
SynonymsL-Leucine-13C
ProtocolIn VitroStable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM7.5660 mL37.8301 mL75.6601 mL151.3203 mL
5mM1.5132 mL7.5660 mL15.1320 mL30.2641 mL
10mM0.7566 mL3.7830 mL7.5660 mL15.1320 mL
20mM0.3783 mL1.8915 mL3.7830 mL7.5660 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.