Calcipotriol (MC903)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1350 | Check With Us |
| 1g | $2050 | Check With Us |
| 5g | $5190 | Check With Us |
: Cat #: V17429 CAS #: 112965-21-6 Purity ≥ 98%
Description: Calcipotriol (MC-903; Daivonex; Dovonex; PRI-2201; Psorcutan; Sorilux) is a synthetic calcitriol/Vitamin D3 (VD3) analog and an agonist of the VD3 receptor.
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- Related Biological Data
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| Molecular Weight (MW) | 412.60 |
|---|---|
| Molecular Formula | C27H40O3 |
| CAS No. | 112965-21-6 |
| SMILES Code | C[C@H](/C=C/[C@H](C1CC1)O)[C@H]([C@]2(CCC/3)C)CC[C@@]2([H])C3=CC=C4C[C@H](O)C[C@@H](O)C4=C |
| Synonyms | Calcipotriene; calcipotriol; Calciptriol; Calcitrene; CCRIS 7700; Daivonex; Dovonex; MC 903; PRI 2201; Psorcutan; Sorilux. |
| Protocol | In Vitro | When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20 and 40 nM in a dose dependent manner. |
|---|---|---|
| In Vivo | One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4237 mL | 12.1183 mL | 24.2365 mL | 48.4731 mL |
| 5mM | 0.4847 mL | 2.4237 mL | 4.8473 mL | 9.6946 mL |
| 10mM | 0.2424 mL | 1.2118 mL | 2.4237 mL | 4.8473 mL |
| 20mM | 0.1212 mL | 0.6059 mL | 1.2118 mL | 2.4237 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.