PF-06446846 hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $935 | Check With Us |
| 250mg | $1745 | Check With Us |
| 500mg | $2615 | Check With Us |
: Cat #: V27359 CAS #: 1632250-50-0 Purity ≥ 99%
Description: PF‑06446846 HCL (PF-6446846; PF6446846) is a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor with anti-hyperlipidemic effects.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 470.35 |
|---|---|
| Molecular Formula | C22H21Cl2N7O |
| CAS No. | 1632250-50-0 |
| SMILES Code | O=C(N(C1=NC=CC=C1Cl)[C@H]2CNCCC2)C3=CC=C(N4N=NC5=CC=CN=C54)C=C3.[H]Cl |
| Synonyms | PF-06446846 hydrochloride; PF-6446846; PF 6446846; PF6446846; PF-06446846 HCl; PF-06446846; PF 06446846; PF06446846; |
| Protocol | In Vitro | PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC50 of 0.3 μM. |
|---|---|---|
| In Vivo | PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1261 mL | 10.6304 mL | 21.2608 mL | 42.5215 mL |
| 5mM | 0.4252 mL | 2.1261 mL | 4.2522 mL | 8.5043 mL |
| 10mM | 0.2126 mL | 1.0630 mL | 2.1261 mL | 4.2522 mL |
| 20mM | 0.1063 mL | 0.5315 mL | 1.0630 mL | 2.1261 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.