Eliglustat tartrate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$1050	Check With Us
1g	$1750	Check With Us
5g	$4430	Check With Us

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Cat #: V5886 CAS #: 928659-70-5 Purity ≥ 99%

Description: Eliglustat tartrate (GENZ-112638; Genz-99067; Cerdelga), the tartrate salt of eliglustat, is a specific and orally bioactive glucocerebroside synthase inhibitor (IC50 = 24 nM) that has been approved by the FDA in August 2014 for the treatment for Gaucher's disease type 1 (GD1).

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Stock Solution Preparation
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Molecular Weight (MW)	959.188
Molecular Formula	C50H78N4O14
CAS No.	928659-70-5
SMILES Code	CCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C3OCCOC3=C2)O)=O
Synonyms	Eliglustat tartrate; Eliglustat hemitartrate; Genz 112638; Genz-112638; Genz112638; Brand name Cerdelga

Protocol	In Vitro	Eliglustat tartrate shows good potency with an IC50 of 24 nM and specificity against the target enzyme.
Protocol	In Vivo	Mice that received drug prior to significant accumulation of substrate (10 weeks of age) showed reduced levels of glucosylceramide and number of Gaucher cells in the spleen, lung and liver when compared to age-matched control animals.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.0425 mL	5.2127 mL	10.4255 mL	20.8510 mL
5mM	0.2085 mL	1.0425 mL	2.0851 mL	4.1702 mL
10mM	0.1043 mL	0.5213 mL	1.0425 mL	2.0851 mL
20mM	0.0521 mL	0.2606 mL	0.5213 mL	1.0425 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.