P7C3

This product is for research use only, not for human use. We do not sell to patients.

P7C3
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$828Check With Us
500mg$1329Check With Us
1g$1995Check With Us

Cat #: V0960 CAS #: 301353-96-8 Purity ≥ 98%

Description: P7C3 (P-7C3; P7 C-3; P 7C3) is a novel and potent proneurogenic and neuroprotective agent that acts by targeting the NAMPT (Nicotinamide phosphoribosyltransferase) enzyme.

References: Pieper AA et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)474.19
Molecular FormulaC21H18Br2N2O
CAS No.301353-96-8
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 95 mg/mL (200.3 mM)r
Water: <1 mg/mLr
Ethanol: 20 mg/mL (42.2 mM)
SMILES CodeOC(CNC1=CC=CC=C1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
SynonymsP7C3; P7 C3; P 7C3
ProtocolIn VitroP7C3 inhibits LPS-induced production of pro-inflammatory factors in BV2 cells.
In VivoP7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1089 mL10.5443 mL21.0886 mL42.1772 mL
5mM0.4218 mL2.1089 mL4.2177 mL8.4354 mL
10mM0.2109 mL1.0544 mL2.1089 mL4.2177 mL
20mM0.1054 mL0.5272 mL1.0544 mL2.1089 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.