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Padnarsertib (KPT-9274)

This product is for research use only, not for human use. We do not sell to patients.

Padnarsertib (KPT-9274)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1000Check With Us
250mg$1800Check With Us
500mg$2700Check With Us

Cat #: V3144 CAS #: 1643913-93-2 Purity ≥ 98%

Description: Padnarsertib (KPT-9274; KPT9274; PAK4-IN-1) is a potent, selective, orally bioavailable small molecule, non-competitive dual inhibitor of PAK4/NAMPT inhibitor with anticancer activity.

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Product Promise

Promise
Molecular Weight (MW)610.63
Molecular FormulaC35H29F3N4O3
CAS No.1643913-93-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 100 mg/mL (163.8 mM)r
Water: < 1 mg/mLr
Ethanol: 100 mg/mL (163.8 mM)
SMILES CodeOC(/C=C/C1=NC(N)=CC=C1)=NCC2=CC3=CC(C4=CC=C(C(N5CCC(F)(F)CC5)=O)C=C4)=CC(C6=CC=C (F)C=C6)=C3O2
SynonymsKPT9274; PAK4-IN-1; KPT-9274; PAK4-IN 1; KPT 9274; PAK4-IN1
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.6377 mL8.1883 mL16.3765 mL32.7531 mL
5mM0.3275 mL1.6377 mL3.2753 mL6.5506 mL
10mM0.1638 mL0.8188 mL1.6377 mL3.2753 mL
20mM0.0819 mL0.4094 mL0.8188 mL1.6377 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.