GNF351

This product is for research use only, not for human use. We do not sell to patients.

GNF351
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1290Check With Us
500mg$1850Check With Us
1g$2775Check With Us

Cat #: V4534 CAS #: 1227634-69-6 Purity ≥ 98%

Description: GNF351 (GNF-351) is a novel and potent full aryl hydrocarbon receptor (AHR) antagonist with the potential to be used as new drugs in dermatology.

References: van den Bogaard EH, et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.

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Product Promise

Promise
Molecular Weight (MW)411.50
Molecular FormulaC24H25N7
CAS No.1227634-69-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeNC1=C2N=C(CCC3=CNC4=C3C=CC=C4)N(C(C)C)C2=NC(C5=CC(C)=CN=C5)=N1
SynonymsGNF351; GNF-351 GNF 351
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4301 mL12.1507 mL24.3013 mL48.6027 mL
5mM0.4860 mL2.4301 mL4.8603 mL9.7205 mL
10mM0.2430 mL1.2151 mL2.4301 mL4.8603 mL
20mM0.1215 mL0.6075 mL1.2151 mL2.4301 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.