BGT226 (NVP-BGT226)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1240 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V0131 CAS #: 1245537-68-1 Purity ≥ 98%
Description: BGT226 maleate (also known as NVP-BGT226 maleate) is a novel and potent dual inhibitor of class I PI3K (phosphatidylinositol 3-kinase)/mammalian target of rapamycin (mTOR) with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 534.53 |
|---|---|
| Molecular Formula | C28H25F3N6O2.C4H4O4 |
| CAS No. | 1245537-68-1 |
| Storage | -20℃ for 3 years in powder form; r |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 30 mg/mL (46.11 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% Propylene glycol: 30mg/mL |
| SMILES Code | O=C(N1C2=CC=C(N3CCNCC3)C(C(F)(F)F)=C2)N(C)C4=C1C5=CC(C6=CC=C(OC)N=C6)=CC=C5N=C |
| Synonyms | BGT226 maleate; BGT 226; BGT-226; NVP-BGT226; NVP-BGT-226; NVP-BGT 226; |
| Protocol | In Vitro | BGT226 shows significant growth inhibition or signal blockage profiles compared with LY294002 and Rapamycin. BGT226 (10-10000 nM) inhibits FaDu and OECM1 cells growth with IC50s of 23.1±7.4 and 12.5±5.1 nM, respectively. |
|---|---|---|
| In Vivo | BGT226 (2.5 and 5 mg/kg; oral administration for 21 days in male athymic mice) causes 34.7% and 76.1% reduction of the tumor growth on day 21 compared with control. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8708 mL | 9.3540 mL | 18.7080 mL | 37.4160 mL |
| 5mM | 0.3742 mL | 1.8708 mL | 3.7416 mL | 7.4832 mL |
| 10mM | 0.1871 mL | 0.9354 mL | 1.8708 mL | 3.7416 mL |
| 20mM | 0.0935 mL | 0.4677 mL | 0.9354 mL | 1.8708 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.