PI3K/mTOR Inhibitor-2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1850 | To Be Confirmed |
| 250mg | $2450 | To Be Confirmed |
| 500mg | $3675 | To Be Confirmed |
: Cat #: V4988 CAS #: 1848242-58-9 Purity ≥ 98%
Description: PI3K/mTOR Inhibitor-2 is a novel and potent dual pan-PI3K/mTOR inhibitor with antitumor activity and with IC50 values of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR.
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- Related Biological Data
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| Molecular Weight (MW) | 478.86 |
|---|---|
| Molecular Formula | C20H13ClF2N4O4S |
| CAS No. | 1848242-58-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | FC1=CC(F)=C(S(=O)(NC2=CC(C(C=C3)=CN4C3=NC=C(Cl)C4=O)=CN=C2OC)=O)C=C1 |
| Synonyms | PI3K/mTOR Inhibitor-2 |
| Protocol | In Vitro | PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0883 mL | 10.4415 mL | 20.8829 mL | 41.7659 mL |
| 5mM | 0.4177 mL | 2.0883 mL | 4.1766 mL | 8.3532 mL |
| 10mM | 0.2088 mL | 1.0441 mL | 2.0883 mL | 4.1766 mL |
| 20mM | 0.1044 mL | 0.5221 mL | 1.0441 mL | 2.0883 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.