Pilaralisib analog (XL147 analog, SAR245408 analog)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$925	Check With Us
500mg	$1280	Check With Us
1g	$1920	Check With Us

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Cat #: V0112 CAS #: 956958-53-5 Purity ≥ 98%

Description: Pilaralisib analog (XL-147 analog, SAR-245408) is novel, selective, potent, orally bioavailable and reversible small molecule inhibitor of Class 1 PI3K (phosphatidylinositol 3 kinase) family of kinases with potential anticancer activity.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	448.52
Molecular Formula	C21H16N6O2S2
CAS No.	956958-53-5
Solubility In Vitro	DMSO: 3 mg/mL (6.68 mM)r
	Water:<1 mg/mL (slightly soluble or insoluble)r
	Ethanol: <1 mg/mL
Solubility In Vivo	30% PEG400+0.5% Tween80+5% Propylene glycol: 15 mg/mL
Synonyms	XL147 analog; XL-147 analog; XL 147 analog; SAR245408 analog; SAR-245408 analog; SAR-245408 analog

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2296 mL	11.1478 mL	22.2955 mL	44.5911 mL
5mM	0.4459 mL	2.2296 mL	4.4591 mL	8.9182 mL
10mM	0.2230 mL	1.1148 mL	2.2296 mL	4.4591 mL
20mM	0.1115 mL	0.5574 mL	1.1148 mL	2.2296 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.