FTI 277 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V0923 CAS #: 180977-34-8 Purity ≥ 98%
Description: FTI 277 HCl (FTI-277; FTI277), the HCl salt of FTI 277, is a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B which is a novel, potent and selective farnesyltransferase (FTase) inhibitor with antiviral activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 484.07 |
|---|---|
| Molecular Formula | C22H30ClN3O3S2 |
| CAS No. | 180977-34-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 96 mg/mL (198.3 mM)r |
| Water: 17 mg/mL (35.1 mM)r | |
| Ethanol: 14 mg/mL (28.9 mM) | |
| SMILES Code | CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl |
| Synonyms | FTI-227 HCl; FTI-277; FTI 277; FTI-227 hydrochloride, FTI277; |
| Protocol | In Vitro | Treatment with FTI-277 (20 microM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types [1]. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner. |
|---|---|---|
| In Vivo | FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0658 mL | 10.3291 mL | 20.6582 mL | 41.3163 mL |
| 5mM | 0.4132 mL | 2.0658 mL | 4.1316 mL | 8.2633 mL |
| 10mM | 0.2066 mL | 1.0329 mL | 2.0658 mL | 4.1316 mL |
| 20mM | 0.1033 mL | 0.5165 mL | 1.0329 mL | 2.0658 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.