Tolcapone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | Check With Us |
| 1g | $750 | Check With Us |
| 5g | $1900 | Check With Us |
: Cat #: V0919 CAS #: 134308-13-7 Purity ≥ 98%
Description: Tolcapone (Ro 40-7592; SOM-0226; Ro-407592; Tasmar), an approved anti-Parkinson's disease (PD) agent, is a reversible and orally bioavailable inhibitor of catechol-O-methyl transferase (COMT) with potential anti-PD effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 273.24 |
|---|---|
| Molecular Formula | C14H11NO5 |
| CAS No. | 134308-13-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 55 mg/mL (201.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 55 mg/mL (201.3 mM) | |
| SMILES Code | O=C(C1=CC([N+]([O-])=O)=C(O)C(O)=C1)C2=CC=C(C)C=C2 |
| Synonyms | SOM0226; Ro 40 7592; Tolcapone, Tasmar, Ro 40-7592; Ro-40-7592; SOM-0226; SOM 0226; |
| Protocol | In Vitro | Tolcapone is cytotoxic to neuroblastoma (NB) cells with IC50 values ranging from 32.27 μM for SMS-KCNR cells to 219.8 μM for MGT9-102-08 primary cells. |
|---|---|---|
| In Vivo | Tolcapone (125 mg/kg; orally) inhibits tumor growth and prolongs survival in vivo. There are no adverse events or differences in weight or behavior noted in the mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6598 mL | 18.2989 mL | 36.5979 mL | 73.1957 mL |
| 5mM | 0.7320 mL | 3.6598 mL | 7.3196 mL | 14.6391 mL |
| 10mM | 0.3660 mL | 1.8299 mL | 3.6598 mL | 7.3196 mL |
| 20mM | 0.1830 mL | 0.9149 mL | 1.8299 mL | 3.6598 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.