Lonafarnib
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1500 | In Stock |
| 500mg | $2350 | In Stock |
| 1g | $3525 | In Stock |
: Cat #: V0916 CAS #: 193275-84-2 Purity ≥ 98%
Description: Lonafarnib (formerly SCH66336; SCH-66336; Sarasar; Zokinvy), a tricyclic derivative of carboxamide, is a novel, orally bioavailable and highly potent FPTase (farnesyl protein transferase) inhibitor with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 638.82 |
|---|---|
| Molecular Formula | C27H31Br2ClN4O2 |
| CAS No. | 193275-84-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 127 mg/mL (198.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 127 mg/mL (198.8 mM) | |
| SMILES Code | O=C(N1CCC(CC(N2CCC([C@@H]3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N |
| Synonyms | Lonafarnib; SCH66336; Trade name: Sarasar; SCH 66336; SCH-66336; |
| Protocol | In Vitro | Lonafarnib (Sch66336) potently inhibits Ha-Ras processing in whole cells and blocks the trans formed growth properties of fibroblasts and human tumor cell lines expressing activated Ki-Ras proteins. |
|---|---|---|
| In Vivo | In mouse, rat, and monkey systems, Lonafarnib (Sch66336) has excellent oral bioavailability and pharmacokinetic properties. In the nude mouse, Lonafarnib demonstrates potent oral activity in a wide array of human tumor xenograft models including tumors of colon, lung, pancreas, prostate, and urinary bladder origin. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5654 mL | 7.8269 mL | 15.6539 mL | 31.3077 mL |
| 5mM | 0.3131 mL | 1.5654 mL | 3.1308 mL | 6.2615 mL |
| 10mM | 0.1565 mL | 0.7827 mL | 1.5654 mL | 3.1308 mL |
| 20mM | 0.0783 mL | 0.3913 mL | 0.7827 mL | 1.5654 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.