JZL195
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $980 | Check With Us |
| 1g | $1470 | Check With Us |
: Cat #: V2822 CAS #: 1210004-12-8 Purity ≥ 98%
Description: JZL195 is a potent, selective and efficacious dual FAAH/MAGL (fatty acid amide hydrolase/monoacylglycerol lipase) inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 433.46 |
|---|---|
| Molecular Formula | C₂₄H₂₃N₃O₅ |
| CAS No. | 1210004-12-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 42 mg/mLr |
| Water: < 1mg/mLr | |
| Ethanol: < 1mg/mL | |
| SMILES Code | O=C(N1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1)OC4=CC=C([N+]([O-])=O)C=C4 |
| Synonyms | JZL195; JZL-195; JZL 195 |
| Protocol | In Vitro | JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays. JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively). |
|---|---|---|
| In Vivo | JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3070 mL | 11.5351 mL | 23.0702 mL | 46.1404 mL |
| 5mM | 0.4614 mL | 2.3070 mL | 4.6140 mL | 9.2281 mL |
| 10mM | 0.2307 mL | 1.1535 mL | 2.3070 mL | 4.6140 mL |
| 20mM | 0.1154 mL | 0.5768 mL | 1.1535 mL | 2.3070 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.