URB597
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $800 | Check With Us |
| 1g | $1250 | Check With Us |
| 5g | $3165 | Check With Us |
: Cat #: V0907 CAS #: 546141-08-6 Purity ≥ 98%
Description: URB597 (also known as KDS4103, URB-597; KDS-4103) is a novel, potent, selective, orally bioavailable fatty acid amide hydrolase (FAAH) inhibitor with antidepressant and analgesic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 338.4 |
|---|---|
| Molecular Formula | C20H22N2O3 |
| CAS No. | 546141-08-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 68 mg/mL (200.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 5 mg/mL (14.8 mM) | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 30mg/mL |
| SMILES Code | O=C(OC1=CC=CC(C2=CC=CC(C(N)=O)=C2)=C1)NC3CCCCC3 |
| Synonyms | KDS-4103, KDS4103, URB597, URB-597, URB 597, KDS 4103 |
| Protocol | In Vitro | URB-597 (KDS-4103) prevents the FAAH-catalyzed hydrolysis of [3H]anandamide by primary cultures of rat cortical neurons with an IC50 value of ~0.50 nM. |
|---|---|---|
| In Vivo | KDS-4103 (0.1-0.3 mg/kg, i.p.) elicits significant, anxiolytic-like, antidepressant-like and analgesic effects, which are prevented by treatment with CB1 receptor antagonists in rats and mice. KDS-4103 is orally available in rats and cynomolgus monkeys. URB-597 (KDS-4103) inhibits rat brain FAAH activity after intraperitoneal (i.p.) administration with a median inhibitory dose (ID50) of 0.15 mg/kg in wild-type mice (+/+) or FAAH-null mice (-/-). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9551 mL | 14.7754 mL | 29.5508 mL | 59.1017 mL |
| 5mM | 0.5910 mL | 2.9551 mL | 5.9102 mL | 11.8203 mL |
| 10mM | 0.2955 mL | 1.4775 mL | 2.9551 mL | 5.9102 mL |
| 20mM | 0.1478 mL | 0.7388 mL | 1.4775 mL | 2.9551 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.