U-104
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $925 | Check With Us |
| 1g | $1480 | Check With Us |
| 5g | $3745 | Check With Us |
: Cat #: V0895 CAS #: 178606-66-1 Purity ≥ 98%
Description: U-104 (MST-104; U104; SLC-0111; NSC-213841) is a novel and potent inhibitor of transmembrane carbonic anhydrase (CA) with potential antineoplastic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 309.32 |
|---|---|
| Molecular Formula | C13H12FN3O3S |
| CAS No. | 178606-66-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 62 mg/mL (200.4 mM)r |
| Water: < 1 mg/mLr | |
| Ethanol: < 1 mg/mL | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL |
| SMILES Code | FC1=CC=C(C=C1)NC(NC2=CC=C(C=C2)S(N)(=O)=O)=O |
| Synonyms | MST-104, SLC0111; SLC 0111; U-104; NSC 213841; MST104; MST 104; NSC-213841; NSC213841; SLC-0111; U104; U 104 |
| Protocol | In Vitro | U-104 has low inhibition for CA I (Ki=5080 nM) and CA II (Ki=9640 nM). U-104 (SLC-0111) is a potent exosome inhibitor. |
|---|---|---|
| In Vivo | U-104 (19, 38 mg/kg; daily; for 27 days) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg; daily; for 5 days) inhibits metastases formation in the 4T1 experimental metastasis mice model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2329 mL | 16.1645 mL | 32.3290 mL | 64.6580 mL |
| 5mM | 0.6466 mL | 3.2329 mL | 6.4658 mL | 12.9316 mL |
| 10mM | 0.3233 mL | 1.6164 mL | 3.2329 mL | 6.4658 mL |
| 20mM | 0.1616 mL | 0.8082 mL | 1.6164 mL | 3.2329 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.