Moclobemide (Ro 111163)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $650 | Check With Us |
| 1g | $1050 | Check With Us |
| 5g | $1575 | Check With Us |
: Cat #: V0904 CAS #: 71320-77-9 Purity ≥ 98%
Description: Moclobemide (Ro-111163; Ro11-1163; Ro 11-1163; Amira; Aurorix; Clobemix; Depnil; Manerix) is a novel, potent, reversible monoamine oxidase MAO-A (5-HT) inhibitor with anti-depressant and anti-anxiety effects.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 268.74 |
|---|---|
| Molecular Formula | C13H17ClN2O2 |
| CAS No. | 71320-77-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (197.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 10 mg/mL (37.2 mM) | |
| Solubility In Vivo | Chemical Name: 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide InChi Key: YHXISWVBGDMDLQ-UHFFFAOYSA-N InChi Code: InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17) SMILES Code: O=C(NCCN1CCOCC1)C2=CC=C(Cl)C=C2 |
| SMILES Code | O=C(NCCN1CCOCC1)C2=CC=C(Cl)C=C2 |
| Synonyms | Ro11-1163; Ro 11-1163; Ro 111163; Moclobemide; Ro111163; Ro-111163; trade name: Amira; Aurorix; Clobemix; Depnil; Manerix. |
| Protocol | In Vitro | NMDA (600 µM for 3 days) inhibits the proliferation of PC12 cells.Moclobemide (2 and 10 µM) up-regulates the proliferation in NMDA-treated PC12 cells. |
|---|---|---|
| In Vivo | Moclobemide is a monoamine oxidase inhibitor and increases the levels of brain monoamines (such as 5-HT, norepinephrine).Moclobemide(40 mg/kg) is effective in animal behavior models. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7211 mL | 18.6053 mL | 37.2107 mL | 74.4214 mL |
| 5mM | 0.7442 mL | 3.7211 mL | 7.4421 mL | 14.8843 mL |
| 10mM | 0.3721 mL | 1.8605 mL | 3.7211 mL | 7.4421 mL |
| 20mM | 0.1861 mL | 0.9303 mL | 1.8605 mL | 3.7211 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.