Methazolamide

This product is for research use only, not for human use. We do not sell to patients.

Methazolamide
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10g$480Check With Us
25g$880Check With Us
50g$1320Check With Us

Cat #: V0900 CAS #: 554-57-4 Purity ≥ 99%

Description: Methazolamide (Neptazaneat; Naptazane; CL-8490; CL8490) is a highly potent and selective inhibitor of carbonic anhydrase (CAI) with important biological activity.

References: Yang F, et al. HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese. Pharmacogenomics J. 2016;16(1):83-87.

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Product Promise

Promise
Molecular Weight (MW)236.27
Molecular FormulaC5H8N4O3S2
CAS No.554-57-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 47 mg/mL (198.9 mM)r
Water: < 1 mg/mLr
Ethanol: 3 mg/mL (12.7 mM)
SMILES CodeCC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C
SynonymsMethenamide; Neptazaneat; Naptazane; CL 8490; Methazolamide; Neptazane; N Methylacetazolamide;N-Methylacetazolamide; CL8490; CL-8490
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.2324 mL21.1622 mL42.3245 mL84.6489 mL
5mM0.8465 mL4.2324 mL8.4649 mL16.9298 mL
10mM0.4232 mL2.1162 mL4.2324 mL8.4649 mL
20mM0.2116 mL1.0581 mL2.1162 mL4.2324 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.