Pyrimethamine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $350 | Check With Us |
| 5g | $650 | Check With Us |
| 10g | $975 | Check With Us |
: Cat #: V0849 CAS #: 58-14-0 Purity ≥ 99%
Description: Pyrimethamine (Malocid; Khloridin; BW 50-63; NCI-C01683; BW50-63; Daraprim; NSC 3061; Tindurin; WR-297; RP-4753) is a potent dihydrofolate reductase (DHFR) inhibitor which is used as an antimalarial and antiprotozoal drug.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 248.71 |
|---|---|
| Molecular Formula | C12H13ClN4 |
| CAS No. | 58-14-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mg/mL (40.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl |
| Synonyms | Malocid; Khloridin; BW 50-63; NCI-C01683; BW-50-63; BW50-63; Daraprim; NSC 3061; Tindurin; WR 297; Chloridine; Ethylpyrimidine; Chloridin; Daraprim; Pirimecidan; Malocide; Pirimetamin; RP 4753; Tindurine |
| Protocol | In Vitro | Pyrimethamine (Pirimecidan; 4 nM-4 μM; 24 h; LLC-MK2 cells with T. gondii) combination of Fluconazole (FLZ) (HY-B0101) inhibits T. gondii activity with IC50 values of 0.23, 0.19, 0.23, 0.34, 0.14, and 0.19 μM for FLZ concentration at 0, 0.05, 0.1, 0.5, 1.0, and 3.0 μM, respectively. |
|---|---|---|
| In Vivo | Pyrimethamine (Pirimecidan; 1 mg/kg; i.g.; daily, for 10 d; female CF1 mice with T. gondii xenograft) combination of Fluconazole (FLZ) (HY-B0101) and Sulfadiazine (HY-B0273) increases protection from death. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.0207 mL | 20.1037 mL | 40.2075 mL | 80.4149 mL |
| 5mM | 0.8041 mL | 4.0207 mL | 8.0415 mL | 16.0830 mL |
| 10mM | 0.4021 mL | 2.0104 mL | 4.0207 mL | 8.0415 mL |
| 20mM | 0.2010 mL | 1.0052 mL | 2.0104 mL | 4.0207 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.