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KY-226

This product is for research use only, not for human use. We do not sell to patients.

KY-226
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1450Check With Us
500mg$2050Check With Us
1g$3075Check With Us
email: [email protected]        [email protected]

Cat #: V34665 CAS #: 1621673-53-7 Purity ≥ 99%

Description: KY-226 is a novel, selective, orally bioactive and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 0.25 μM, and without PPARγ agonist activity.

References: Ito Y, et al. Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice. J Pharmacol Sci. 2018 May;137(1):38-46.

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Molecular Weight (MW)481.67
Molecular FormulaC27H31NO3S2
CAS No.1621673-53-7
SMILES Code O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1
SynonymsKY-226; KY 226; KY226;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.0761 mL10.3806 mL20.7611 mL41.5222 mL
5mM0.4152 mL2.0761 mL4.1522 mL8.3044 mL
10mM0.2076 mL1.0381 mL2.0761 mL4.1522 mL
20mM0.1038 mL0.5190 mL1.0381 mL2.0761 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.