Baicalein | CAS 491-67-8

Baicalein

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
5g	$600	In Stock
10g	$960	In Stock
20g	$1440	In Stock

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Cat #: V0807 CAS #: 491-67-8 Purity ≥ 98%

Description: Baicalein (5,6,7-Trihydroxyflavone; Noroxylin; BaiKalein), a naturally occuring flavone, is a potent inhibitor of CYP2C9, prolyl endopeptidase, and xanthine oxidase with important biological activity (e.g, antioxidant, anti-inflammation, antifibrotic).

References: Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct;20(5A):2861-5.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	270.24
Molecular Formula	C15H10O5
CAS No.	491-67-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 54 mg/mL (199.8 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	O=C1C=C(C2=CC=CC=C2)OC3=C1C(O)=C(O)C(O)=C3
Synonyms	Noroxylin; 5,6,7-Trihydroxyflavone; Baicalein; BaiKalein;

Protocol	In Vitro	Baicalein suppresses mitogen induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb induced proliferation as well as cytokine secretion at 25 μM. Baicalein treatment induces DNA binding of NF-κB but inhibits thioredoxin activity in the nuclear compartment.
Protocol	In Vivo	Baicalein suppresses induction of graft versus host disease but does not inhibit homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.7004 mL	18.5021 mL	37.0041 mL	74.0083 mL
5mM	0.7401 mL	3.7004 mL	7.4008 mL	14.8017 mL
10mM	0.3700 mL	1.8502 mL	3.7004 mL	7.4008 mL
20mM	0.1850 mL	0.9251 mL	1.8502 mL	3.7004 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.