Apigenin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $550 | Check With Us |
| 5g | $850 | Check With Us |
| 10g | $1275 | Check With Us |
: Cat #: V0808 CAS #: 520-36-5 Purity ≥ 98%
Description: Apigenin (NSC-83244, LY-080400; 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1) is a natural flavonoid acting as a potent P450 inhibitor with various biological activity (e.g, antioxidant, anti-inflammation, anticancer).
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 270.24 |
|---|---|
| Molecular Formula | C15H10O5 |
| CAS No. | 520-36-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 54 mg/mL (199.8 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13 |
| Synonyms | LY080400; NSC-83244, LY-080400; NSC83244, NSC 83244, LY 080400; Apigenine; Chamomile; Apigenol; Spigenin; Versulin; 457Trihydroxyflavone; C.I. Natural Yellow 1 |
| Protocol | In Vitro | Apigenin (4',5,7-Trihydroxyflavone) inhibits cytochrome P450 2C9 (CYP2C9) with a Ki of 2 μM in the CYP2C9 RECO system (a purified, reconstituted enzyme system containing recombinant human CYP2C9, P450 reductase, cytochrome b5, and liposomes). |
|---|---|---|
| In Vivo | Apigenin (4',5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. Apigenin (125 mg/kg and 250 mg/kg) alleviates Adriamycin (ADR) (24 mg/kg)-induced myocardial injury. Apigenin inhibits serum aspartate amino transferase (AST) release. Apigenin reduces serum lactate dehydrogenase (LDH) release. Apigenin reduces serum creatine kinase (CK) contents. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7004 mL | 18.5021 mL | 37.0041 mL | 74.0083 mL |
| 5mM | 0.7401 mL | 3.7004 mL | 7.4008 mL | 14.8017 mL |
| 10mM | 0.3700 mL | 1.8502 mL | 3.7004 mL | 7.4008 mL |
| 20mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 3.7004 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.