Phenprocoumon (Marcumar

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$445	Check With Us
1g	$700	Check With Us
5g	$1770	Check With Us

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Cat #: V5245 CAS #: 435-97-2 Purity ≥ 98%

Description: Phenprocoumon (Marcumar), a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K, is a vitamin K reductase with an IC50 of 1 μM. Phenprocoumon inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders.

References: [1]. Straubhaar B, et al. The prevalence of potential drug-drug interactions in patients with heart failure at hospital discharge. Drug Saf. 2006;29(1):79-90.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	280.32
Molecular Formula	C18H16O3
CAS No.	435-97-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	CCC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O
Synonyms	Marcoumar, Marcumar and Falithrom; Phenprocoumon; Phenprocoumarol; Marcumar; Phenprocoumarole; Falithrom

Protocol	In Vivo	After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5674 mL	17.8368 mL	35.6735 mL	71.3470 mL
5mM	0.7135 mL	3.5674 mL	7.1347 mL	14.2694 mL
10mM	0.3567 mL	1.7837 mL	3.5674 mL	7.1347 mL
20mM	0.1784 mL	0.8918 mL	1.7837 mL	3.5674 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.