This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | To Be Confirmed |
| 500mg | $1950 | To Be Confirmed |
| 1g | $2925 | To Be Confirmed |
: Cat #: V5248 CAS #: 2230724-66-8 Purity ≥ 98%
Description: BTK inhibitor 27, compound 27 in the cited reference below, is a pyrrolo[2,3-d]pyrimidine based BTK inhibitor with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM. Btk is a tyrosine kinase dysregulated in several B-cell malignancies and autoimmune diseases, and this has given rise to a search for Btk inhibitors. Nevertheless, only one Btk inhibitor, ibrutinib, has been approved to date, although other compounds are currently being evaluated in clinical trials or in preclinal stages.
References: Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318.
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| Molecular Weight (MW) | 474.49 |
|---|---|
| Molecular Formula | C24H23FN8O2O |
| CAS No. | 2230724-66-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Synonyms | BTK inhibitor 1 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1075 mL | 10.5376 mL | 21.0753 mL | 42.1505 mL |
| 5mM | 0.4215 mL | 2.1075 mL | 4.2151 mL | 8.4301 mL |
| 10mM | 0.2108 mL | 1.0538 mL | 2.1075 mL | 4.2151 mL |
| 20mM | 0.1054 mL | 0.5269 mL | 1.0538 mL | 2.1075 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.