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CRBN modulator 1

This product is for research use only, not for human use. We do not sell to patients.

CRBN modulator 1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$750Check With Us
250mg$1350Check With Us
500mg$2025Check With Us
email: [email protected]        [email protected]

Cat #: V41476 CAS #: 2407829-65-4 Purity ≥ 99%

Description: CRBN modulator 1 is a thalidomide analog and a CRBN modulator (IC50 = 3.5 μM and Ki = 0.98 μM) disclosed in WO 2020006262.

References: Nathanael Gray, et al. New crbn modulators. WO2020006262A1.

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Molecular Weight (MW)324.29
Molecular FormulaC17H12N2O5
CAS No.2407829-65-4
SMILES CodeO=C(C1=C2C(C=C(O)C=C23)=CC=C1)N(C4CCC(NC4=O)=O)C3=O
SynonymsWUN29654; WUN-29654; WUN 29654;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0837 mL15.4183 mL30.8366 mL61.6732 mL
5mM0.6167 mL3.0837 mL6.1673 mL12.3346 mL
10mM0.3084 mL1.5418 mL3.0837 mL6.1673 mL
20mM0.1542 mL0.7709 mL1.5418 mL3.0837 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.