E3 Ligase Ligand-Linker Conjugates 52 (TFA)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $600 | Check With Us |
| 500mg | $950 | Check With Us |
| 1g | $1425 | Check With Us |
: Cat #: V31913 CAS #: 2022182-58-5 Purity ≥ 99%
Description: E3 Ligase Ligand-Linker Conjugates 52 TFA (Compound 10) incorporates a CRBN ligand for the E3 ubiquitin ligase, and a PROTAC linker.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 502.40 |
|---|---|
| Molecular Formula | C20H21F3N4O8 |
| CAS No. | 2022182-58-5 |
| SMILES Code | O=C(NCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.OC(C(F)(F)F)=O |
| Synonyms | E3 Ligase Ligand-Linker Conjugates 52 (TFA) |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9904 mL | 9.9522 mL | 19.9045 mL | 39.8089 mL |
| 5mM | 0.3981 mL | 1.9904 mL | 3.9809 mL | 7.9618 mL |
| 10mM | 0.1990 mL | 0.9952 mL | 1.9904 mL | 3.9809 mL |
| 20mM | 0.0995 mL | 0.4976 mL | 0.9952 mL | 1.9904 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.