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Azido-PEG4-alcohol

This product is for research use only, not for human use. We do not sell to patients.

Azido-PEG4-alcohol
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$350Check With Us
1g$450Check With Us
5g$1140Check With Us

Cat #: V10173 CAS #: 86770-67-4 Purity ≥ 98%

Description: Azido-PEG4-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.

References: Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

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Product Promise

Promise
Molecular Weight (MW)219.24
CAS No.86770-67-4
SMILES CodeOCCOCCOCCOCCN=[N+]=[N-]
SynonymsAzido-PEG4-alcohol
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.5612 mL22.8061 mL45.6121 mL91.2242 mL
5mM0.9122 mL4.5612 mL9.1224 mL18.2448 mL
10mM0.4561 mL2.2806 mL4.5612 mL9.1224 mL
20mM0.2281 mL1.1403 mL2.2806 mL4.5612 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.