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6-Maleimidocaproic acid

This product is for research use only, not for human use. We do not sell to patients.

6-Maleimidocaproic acid
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$30In Stock
5g$65In Stock
10g$100In Stock

Cat #: V5631 CAS #: 55750-53-3 Purity ≥ 98%

Description: 6-Maleimidocaproic acid is a biochemical that contains a maleimide group and a terminal carboxylic acid.

References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Molecular Weight (MW)211.21
Molecular FormulaC10H13NO4
CAS No.55750-53-3
SMILES CodeO=C1C=CC(N1CCCCCC(O)=O)=O
Synonyms6-Maleimidocaproic acid
ProtocolIn VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.7346 mL23.6731 mL47.3462 mL94.6925 mL
5mM0.9469 mL4.7346 mL9.4692 mL18.9385 mL
10mM0.4735 mL2.3673 mL4.7346 mL9.4692 mL
20mM0.2367 mL1.1837 mL2.3673 mL4.7346 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.