Bromo-PEG2-azide

This product is for research use only, not for human use. We do not sell to patients.

Bromo-PEG2-azide
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$699Check With Us
1g$999Check With Us
5g$2529Check With Us

Cat #: V17096 CAS #: 530151-56-5 Purity ≥ 98%

Description: Bromo-PEG2-azide is a PEG analogue containing a bromide group and a terminal azide.

References: Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.

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Molecular Weight (MW)238.08
Molecular FormulaC6H12BrN3O2
CAS No.530151-56-5
SMILES CodeBrCCOCCOCCN=[N+]=[N-]
SynonymsBromo-PEG2-azide
ProtocolIn VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.2003 mL21.0013 mL42.0027 mL84.0054 mL
5mM0.8401 mL4.2003 mL8.4005 mL16.8011 mL
10mM0.4200 mL2.1001 mL4.2003 mL8.4005 mL
20mM0.2100 mL1.0501 mL2.1001 mL4.2003 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.