Home > Product Type>PROTACs>PROTAC Linkers>Amino-PEG2-t-butyl ester
Amino-PEG2-t-butyl ester

This product is for research use only, not for human use. We do not sell to patients.

Amino-PEG2-t-butyl ester
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$400Check With Us
5g$800Check With Us
10g$1200Check With Us

Cat #: V8373 CAS #: 756525-95-8 Purity ≥ 98%

Description: Amino-PEG2-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.

References: Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)233.30
Molecular FormulaC11H23NO4
CAS No.756525-95-8
SMILES CodeO=C(OC(C)(C)C)CCOCCOCCN
SynonymsAmino-PEG2-t-butyl ester
ProtocolIn VitroPROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.2863 mL21.4316 mL42.8633 mL85.7265 mL
5mM0.8573 mL4.2863 mL8.5727 mL17.1453 mL
10mM0.4286 mL2.1432 mL4.2863 mL8.5727 mL
20mM0.2143 mL1.0716 mL2.1432 mL4.2863 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.