TGN-020
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | In Stock |
| 500mg | $750 | In Stock |
| 1g | $1125 | In Stock |
: Cat #: V4048 CAS #: 51987-99-6 Purity ≥ 98%
Description: TGN-020 (TGN020) is a novel and potent inhibitor of aquaporin 4 (AQP4) channel (IC50: 3.1 μM), which is the most abundant water channel in the brain.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 206.22 |
|---|---|
| Molecular Formula | C8H6N4OS |
| CAS No. | 51987-99-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(C1=CC=CN=C1)NC2=NN=CS2 |
| Synonyms | TGN-020; TGN 020; TGN020 |
| Protocol | In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
|---|---|---|
| In Vivo | TGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.8492 mL | 24.2460 mL | 48.4919 mL | 96.9838 mL |
| 5mM | 0.9698 mL | 4.8492 mL | 9.6984 mL | 19.3968 mL |
| 10mM | 0.4849 mL | 2.4246 mL | 4.8492 mL | 9.6984 mL |
| 20mM | 0.2425 mL | 1.2123 mL | 2.4246 mL | 4.8492 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
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×
Volume(start)
V1
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Concentration(final)
C2
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Volume(final)
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.